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Lestaurtinib, Tocris Bioscience™

Product Code. 18045682
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Quantity:
1 mg
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Description

JAK2, FLT3 and TrkA inhibitor; also inhibits AurA and AurB

Potent JAK2, FLT3 and TrkA inhibitor (IC50 values are 0.9, 3 and < 25 nM, respectively). Also inhibits Aurora kinase A and B (IC50 values are 8.1 and 2.3 nM, respectively) and prevents STAT5 phosphorylation (IC50 = 20 - 30 nM). Exhibits antiproliferative activity in vitro (IC50 = 30 - 100 nM in HEL92.1.7 cells) and is effective against myeloproliferative disorders in vivo.

Specifications

CAS 111358-88-4
Molecular Formula C26H21N3O4
MDL Number MFCD09840836,MFCD12828858
Quantity 1 mg
Synonym lestaurtinib, unii-do989gc5d1, lestaurtinib usan/inn, 9,12-epoxy-1h-diindolo 1,2,3-fg:3',2',1'-kl pyrrolo 3,4-i 1,6 benzodiazocin-1-one, 2,3,9,10,11,12-hexahydro-10-hydroxy-10-hydroxymethyl-9-methyl-, 9s,10s,12r, lestaurtinib usan:inn, 4otg, d0v9wf, dsstox_cid_26778, dsstox_rid_81897
InChI Key UIARLYUEJFELEN-LROUJFHJSA-N
SMILES C[C@]12O[C@H](C[C@]1(O)CO)N1C3=C(C=CC=C3)C3=C1C1=C(C4=C3C(=O)NC4)C3=CC=CC=C3N21
IUPAC Name (15S,16S,18R)-16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1¹⁵,¹⁸.0²,⁶.0⁷,²⁷.0⁸,¹³.0¹⁹,²⁶.0²⁰,²⁵]octacosa-1(26),2(6),7(27),8,10,12,20(25),21,23-nonaen-3-one
Molecular Weight (g/mol) 439.47
PubChem CID 126565
Formula Weight 439.46
Percent Purity >99%
Chemical Name or Material Lestaurtinib
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