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LRP5 Monoclonal Antibody (2B11), Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen MA517113
This item is not returnable.
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Description
MA5-17113 targets LRP5 in FACS, indirect ELISA, and WB applications and shows reactivity with Human samples. The MA5-17113 immunogen is purified recombinant fragment of human LRP5 expressed in E. Coli. MA5-17113 detects LRP5 which has a predicted molecular weight of approximately 179kDa.
LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization.
Specifications
| LRP5 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 0.05% sodium azide | |
| O75197 | |
| LRP5 | |
| Purified recombinant fragment of human LRP5 expressed in E. Coli. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| ELISA, Flow Cytometry, Western Blot | |
| 2B11 | |
| Unconjugated | |
| LRP5 | |
| BMND1; EVR1; EVR4; HBM; HGNC:6697; LDL receptor related protein 5; low density lipoprotein receptor-related protein 5; low density lipoprotein receptor-related protein 7; low-density lipoprotein receptor-related protein 5; Low-density lipoprotein receptor-related protein 7; LR3; Lrp5; LRP-5; LRP7; LRP-7; mKIAA4142; OPPG; OPS; OPTA1; VBCH2 | |
| Mouse | |
| Protein G | |
| RUO | |
| 4041 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |