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Meclizine dihydrochloride, Tocris Bioscience™
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Quantity:
50 mg
Description
Meclizine dihydrochloride is a human pregnane X receptor (hPXR) agonist; it is a more potent activator of hPXR than rat PXR. Meclizine increases hPXR target gene expression in human hepatocyte primary cultures. It also acts as a histamine H1 receptor antagonist. Meclizine attenuates mitochondrial respiration and increases glycolysis. The product inhibits rotenone-induced cell death in stem cell-derived dopaminergic neuronal culture and confers neuroprotection in models of polyglutamine (polyQ) toxicity.
Specifications
Specifications
| CAS | 1104-22-9 |
| Molecular Formula | C25H29Cl3N2 |
| Quantity | 50 mg |
| Synonym | meclizine dihydrochloride, meclozine dihydrochloride, bonamine, meclizine hydrochloride, postafen, vertizine, taizer, v-cline, 1-4-chlorophenyl phenyl methyl-4-3-methylbenzyl piperazine dihydrochloride, duremesin |
| InChI Key | VCTHNOIYJIXQLV-UHFFFAOYSA-N |
| SMILES | CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl.Cl.Cl |
| IUPAC Name | 1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine;dihydrochloride |
| Molecular Weight (g/mol) | 463.871 |
| PubChem CID | 64713 |
| Formula Weight | 463.87 |
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