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ML 323, Tocris Bioscience™
Potent and selective USP1-UAF1 allosteric inhibitor
Brand: Tocris Bioscience 6435/25
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Description
ML 323 is a potent and selective allosteric inhibitor of USP1-UAF1 deubiquitinase complex (IC50 = 76 nM). Exhibits selectivity for USP1-UAF1 over a panel of enzymes, including other deuquitinating enzymes. Inhibits deubiquitination of PCNA and FANCD2 and sensitizes cisplatin-resistant H596 cells to cell death induced by cisplatin (Cat. No. 2251) in vitro.Specifications
| 1572414-83-5 | |
| 5-Methyl-2-[2-(1-methylethyl)phenyl]-N-[[4-(1H-1,2,3-triazol-1-yl)phenyl]methyl]-4-pyrimidinamine | |
| 25 mg |