NGAL Monoclonal Antibody (26), Invitrogen™

Description

Specificity: ABS 038-26-02 does not cross-react with NGAL from other mammalian species tested. Reactivity: ABS 038-26-02 binds human NGAL in solution and coated onto a solid phase. ABS 038-26-02 can be used as a capture antibody in a sandwich ELISA using biotinylated detection antibodies HYB 211-01-02, ABS 038-14-02, ABS 038-15-02 and ABS 038-23-02. NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL

NGAL (Neutrophil gelatinase-associated lipocalin, lipocalin 2, siderocalin and neutrophil lipocalin) is a 25 kDa glycosylated single chain monomer and member of the lipocalin family of proteins that bind and transport small lipophilic molecules. NGAL is released by activated neutrophils, can form dimers and small amounts of higher oligomers, and complexes with matrix metalloproteinase 9 (MMP-9, gelatinase B). Low level expression of NGAL in a variety of epithelia may be increased in inflammation or cancers. Expression of NGAL in the kidney is dramatically increased by ischemic or nephrotoxic kidney injury.