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Eurofins DiscoverX PDGFRβ Protein, Active
Active, recombinant human PDGF Receptor β, residues 557-end, containing an N-terminal His6-tag, for use in Kinase Assays.
Brand: Eurofins DiscoverX 14-463M
This item is not returnable.
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Description
Receptors that are tyrosine protein kinases include those receptors for platelet-derived growth factor (PDGF), insulin, epidermal growth factor (EGF) and certain lymphokines. Receptor tyrosine kinases are cell surface transmembrane proteins responsible for intracellular signal transduction. They are expressed in several cell types and, after activation by growth factor binding, trigger a series of intracellular pathways leading to a wide variety of responses; e.g. differentiation, proliferation, migration and invasion, angiogenesis, survival. Inhibition of PDGFRB (PDGFR1, JTK12, CD140B,Beta platelet-derived growth factor) receptor kinase may be useful in the treatment of several tumors.
GenBank J03278
Specifications
| mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 0.1 mM EGTA, 150 mM NaCl, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. | |
| 250 μg | |
| Recombinant | |
| Recombinant enzyme expressed in Sf21 insect cells | |
| ≥65% |
| 64 kDa | |
| Human | |
| N-terminal 6His | |
| Truncated | |
| PDGFR beta, active |
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Product Title
Eurofins DiscoverX PDGFRβ Protein, Active
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