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Tocris Bioscience™ PF 06409577
Potent and selective allosteric activator of AMPK
Brand: Tocris Bioscience™ 6114/10
Additional Details : CAS Number : 1467057-23-3 Weight : 0.00970kg
Description
PF 06409577 is a potent and selective allosteric activator of AMPK (EC50 values are 7 and >40000 nM for AMPKα1β1γ1 and AMPKα1β2γ1, respectively). Exhibits minimal off-target effects on a panel of receptors, ion channels, PDEs and kinases. Improves kidney function and reduces proteinuria in a preclinical model of diabetic nephropathy. Orally bioavailable.Specifications
PF 06409577 | |
6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid | |
Soluble to 100mM in DMSO and to 20mM in ethanol | |
Gray |
1467057-23-3 | |
10 mg | |
Solid | |
Bioactive Small Molecule |
For Research Use Only.