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Tocris Bioscience™ PF 06409577

Potent and selective allosteric activator of AMPK

Brand: Tocris Bioscience™ 6114/10

Additional Details : CAS Number : 1467057-23-3 Weight : 0.00970kg

Product Code. 15727226

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Description

PF 06409577 is a potent and selective allosteric activator of AMPK (EC50 values are 7 and >40000 nM for AMPKα1β1γ1 and AMPKα1β2γ1, respectively). Exhibits minimal off-target effects on a panel of receptors, ion channels, PDEs and kinases. Improves kidney function and reduces proteinuria in a preclinical model of diabetic nephropathy. Orally bioavailable.

Specifications

Chemical Name or Material	PF 06409577
Synonym	6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid
Solubility	Soluble to 100mM in DMSO and to 20mM in ethanol
Color	Gray

CAS	1467057-23-3
Quantity	10 mg
Physical Form	Solid
Product Type	Bioactive Small Molecule

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Tocris Bioscience™ PF 06409577

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