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PF 184, Tocris Bioscience™

Catalog Number 18014332
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Quantity:
10 mg
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Description

Potent and selective IKKβ inhibitor

Potent and selective IKKβ inhibitor (IC50 = 37 nM). Displays selectivity over 85 other kinases. Inhibits IL-1β-induced TNF-α production in a steroid-insensitive in vitro model of oxidative stress.
CAS 1187460-81-6
Molecular Formula C32H32ClFN6O4
Quantity 10 mg
Synonym 8-[[[5-Chloro-2-[3,4-dimethyl-3,4-bis(hydroxymethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide
InChI Key JUOWWGNRWRLBSV-UHFFFAOYSA-N
SMILES CC1(CN(CC1(C)CO)C2=NC=C(C(=C2)C(=O)NC3=CC4=C(CCC5=C4N(N=C5C(=O)N)C6=CC=C(C=C6)F)C=C3)Cl)CO
IUPAC Name 8-[[2-[3,4-bis(hydroxymethyl)-3,4-dimethylpyrrolidin-1-yl]-5-chloropyridine-4-carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydrobenzo[g]indazole-3-carboxamide
Molecular Weight (g/mol) 619.094
PubChem CID 76553518
Formula Weight 619.09
Percent Purity >98%
Chemical Name or Material PF 184
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