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STEMCELL Technologies Rapamycin

Antibiotic; mTOR pathway inhibitor; Inhibits FKBP-12

Brand: STEMCELL Technologies 73364

Product Code. 17130212

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Description

Rapamycin is a macrolide antibiotic and immunosuppressive compound that inhibits mammalian target of rapamycin (mTOR) signaling
It acts through formation of a complex with cytosolic FK-binding protein 12 (FKBP-12), which directly binds to mTOR complex 1 (mTORC1)
Its immunosuppressive effects are mediated through inhibition of IL-2 signaling that is critical for T-cell proliferation and activation (Gibbons et al.; Kay et al.) Rapamycin shows antifungal activity against Candida albicans and other fungi (Vézina et al.)
Inhibits growth of MDA-MB-468 human breast cancer cells in vitro, and inhibits tumor growth in a mouse xenograft model in vivo (Akcakanat et al.)
Induces autophagy in malignant glioma cells (Takeuchi et al.)

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