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RBM28 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA555371
This item is not returnable.
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Description
Immunogen sequence: EHSKGCAFAQ FMTQEAAQKC LLAASPENEA GGLKLDGRQL KVDLAVTRDE AAKLQTTKVK KPTGTRNLYL AREGLIRAGT KAAEGVSAAD MAKRERFELL KHQKLKDQNI FVSRTR Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.
Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3. Also binds 25-hydroxycholesterol and cholesterol.
Specifications
| RBM28 | |
| Polyclonal | |
| Unconjugated | |
| Rbm28 | |
| 2810480G15Rik; AI503051; ANES; hypothetical protein MGC56258; RBM28; RNA binding motif protein 28; RNA-binding motif protein 28; RNA-binding protein 28; zgc:56258 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 312182, 55131, 68272 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunocytochemistry, Immunohistochemistry, Western Blot | |
| 0.1 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q8CGC6, Q9NW13 | |
| Rbm28 | |
| Recombinant protein corresponding to Human RBM28 | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
Research Use Only