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Tocris Bioscience™ SAG

Potent Smoothened receptor agonist; activates the Hedgehog signaling pathway

Brand:  Tocris Bioscience™ 4366/10

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Product Code. 18024052

  • 8955.00 SEK / 10mg

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Description

Description

SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); antagonizes Cyclopamine (Cat. No. 1623) action at the Smo receptor. SAG potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ∼ 3 nM) and nduces pathway activation independently of Ptch proteins. SAG is a putative inhibitor of a cellular component required for Hedgehog signaling and also enhances neuronal differentiation of iPSCs into dopaminergic neurons.

SAG dihydrochloride (Cat. No. 6390) also available.

Specifications

Specifications

>99%
SAG
SAG
10 mg
490.06
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