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  6. SB 202190, Tocris Bioscience™

SB 202190, Tocris Bioscience™

Catalog Number 18054982
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
152121-30-7
C20H14FN3O
331.35
MFCD00941964
NJNKPVPFGLGHPA-UHFFFAOYSA-N
fhpi, unii-pvx798p8gi, 4-4-fluorophenyl-2-4-hydroxyphenyl-5-4-pyridyl imidazole, 4-4-fluorophenyl-2-4-hydroxyphenyl-5-4-pyridyl-1h-imidazole, pvx798p8gi, sb 202190, immobilized, insolution sb 202190, 4-4-4-fluorophenyl-5-pyridin-4-yl-1h-imidazol-2-yl phenol, phenol, 4-4-4-fluorophenyl-5-4-pyridinyl-1h-imidazol-2-yl
5353940
4-[4-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydro-1H-imidazol-2-ylidene]cyclohexa-2,5-dien-1-one
FC1=CC=C(C=C1)C1=C(NC(N1)=C1C=CC(=O)C=C1)C1=CC=NC=C1
This item is not returnable. View return policy
152121-30-7
C20H14FN3O
331.35
MFCD00941964
NJNKPVPFGLGHPA-UHFFFAOYSA-N
fhpi, unii-pvx798p8gi, 4-4-fluorophenyl-2-4-hydroxyphenyl-5-4-pyridyl imidazole, 4-4-fluorophenyl-2-4-hydroxyphenyl-5-4-pyridyl-1h-imidazole, pvx798p8gi, sb 202190, immobilized, insolution sb 202190, 4-4-4-fluorophenyl-5-pyridin-4-yl-1h-imidazol-2-yl phenol, phenol, 4-4-4-fluorophenyl-5-4-pyridinyl-1h-imidazol-2-yl
5353940
4-[4-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydro-1H-imidazol-2-ylidene]cyclohexa-2,5-dien-1-one
FC1=CC=C(C=C1)C1=C(NC(N1)=C1C=CC(=O)C=C1)C1=CC=NC=C1

Description

Potent, selective inhibitor of p38 MAPK

SB 202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase. Binds within the ATP pocket of the active kinase (Kd = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38α and β isoforms (IC50 = 50 and 100 nM at SAPK2a/p38 and SAPK2b/p38β2 respectively). Promotes stability of naive human pluripotent stem cells in culture. Inhibits Yamanaka factor reprogramming of human fibroblasts to iPSCs. SB 202190 improves the self-renewal ability of neuronal stem cells from NPC1-deficient mice.
Quantity 50 mg
Formula Weight 331.35
Percent Purity >99%
Chemical Name or Material SB 202190
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