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TC-S 7009, Tocris Bioscience™
High affinity and selective HIF-2α inhibitor
Brand: Tocris Bioscience 5243/5
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Description
TC-S 7009 is a high affinity and selective HIF-2α inhibitor (Kd = 81 nM). Binds to the HIF-2α PAS-B domain; disrupts HIF-2α-ARNT heterodimerization. Exhibits >60-fold selectivity for HIF-2α over HIF-1α. Decreases HIF-2α DNA-binding and attenuates expression of HIF-2α target genes in vitro.Specifications
| N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine | |
| 1422955-31-4 | |
| >99% | |
| 5 mg |