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TDP-43 Rabbit anti-Human, Mouse, Rat, Zebrafish, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 10782-2-AP-20UL
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Description
Proteintech's 10782-2-AP antibody is a rabbit polyclonal antibody recognizing N-terminal TDP-43. It recognizes the intact 45 kDa protein as well as all post translationally modified and truncated forms in multiple applications. Various forms of TDP-
TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3"e; splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.Specifications
| TDP-43 | |
| Polyclonal | |
| Unconjugated | |
| TARDBP | |
| ALS10, TAR DNA binding protein, TAR DNA binding protein 43, TARDBP, TDP 43, TDP43 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 230908, 23435, 298648, 325052 | |
| -20°C | |
| Liquid |
| Immunocytochemistry, Immunohistochemistry (Paraffin), Immunofluorescence, Immunohistochemistry, Flow Cytometry | |
| 0.31 mg/mL | |
| PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
| Q13148, Q921F2 | |
| tardbp | |
| TDP-43 Fusion Protein Ag1231 | |
| 20 μL | |
| Primary | |
| Rat, Zebrafish, Mouse, Human | |
| Antibody | |
| IgG |
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