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  7. Trifluoroacetic anhydride, 99+%, Thermo Scientific Chemicals

Trifluoroacetic anhydride, 99+%, Thermo Scientific Chemicals

Product Code. 11470174
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Description

Trifluoroacetic anhydride is used for the introduction of trifluoroacetyl group in organic synthesis. It is involved in the preparation of N- and O-trifluoroacetyl derivatives of a wide range of biologically active compounds for gas chromatography analysis. It plays an important role as desiccant for trifluoroacetic acid. It is also used in the oxidation of aldehydes to acids, esters, amides as well as in the protection of alcohols and amines. In addition, it is used as analytical reagents, solvents and dehydration condensing agent. It serves as an intermediate of fluorine fine chemicals, pharmaceuticals and agrochemicals.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Trifluoroacetic anhydride is used for the introduction of trifluoroacetyl group in organic synthesis. It is involved in the preparation of N- and O-trifluoroacetyl derivatives of a wide range of biologically active compounds for gas chromatography analysis. It plays an important role as desiccant for trifluoroacetic acid. It is also used in the oxidation of aldehydes to acids, esters, amides as well as in the protection of alcohols and amines. In addition, it is used as analytical reagents, solvents and dehydration condensing agent. It serves as an intermediate of fluorine fine chemicals, pharmaceuticals and agrochemicals.

Solubility
Miscible with benzene, dichloromethane, diethyl ether, dimethylformamide, terahydrofuran and acetonitrile.

Notes
Hygroscopic and moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents, strong bases, strong acids, and alcohols.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 407-25-0
Molecular Formula C4F6O3
Molecular Weight (g/mol) 210.03
MDL Number MFCD00000416
InChI Key QAEDZJGFFMLHHQ-UHFFFAOYSA-N
Synonym trifluoroacetic anhydride, trifluoroacetic acid anhydride, 2,2,2-trifluoroacetic anhydride, bis trifluoroacetic anhydride, acetic acid, trifluoro-, anhydride, perfluoroacetic anhydride, trifluoroacetyl anhydride, tfaa, hexafluoroacetic anhydride, anhydrid kyseliny trifluoroctove
PubChem CID 9845
SMILES FC(F)(F)C(=O)OC(=O)C(F)(F)F

Specifications

Melting Point -65°C
Density 1.503
Boiling Point 39°C to 40°C
Linear Formula (CF3CO)2O
Refractive Index 1.269
Quantity 500 g
UN Number UN3265
Beilstein 746197
Sensitivity Moisture sensitive
Solubility Information Miscible with benzene,dichloromethane,diethyl ether,dimethylformamide,terahydrofuran and acetonitrile.
IUPAC Name (2,2,2-trifluoroacetyl) 2,2,2-trifluoroacetate
Formula Weight 210.03
Percent Purity ≥99%
Chemical Name or Material Trifluoroacetic anhydride
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Safety and Handling

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Signal Word
  • Danger
 Hazard Category
  • Acute toxicity Category 4
  • LONG-TERM AQUATIC HAZARD Chronic 3
  • Serious eye damage/eye irritation Category 1
  • Reproductive toxicity Category 2
  • Skin corrosion/irritation Category 1 A
 Hazard Statement
  • H314-Causes severe skin burns and eye damage.
  • H332-Harmful if inhaled.
  • H361d-Suspected of damaging the unborn child.
  • H412-Harmful to aquatic life with long lasting effects.
  • EUH014-Reacts violently with water.
 Precautionary Statement
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
  • P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
  • P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
  • P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P310-Immediately call a POISON CENTER/doctor/.

RUO – Research Use Only

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