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(±)-Verapamil Hydrochloride, MP Biomedicals™

Catalog Number 11425502
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Quantity:
1 g
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Description

Functions as a calcium channel modulator, adrenoceptor antagonist, anti-arrhythmic, cardiac depressant, and coronary vasodilator. (±)-Verapamil Hydrochloride, MP Biomedicals is an α1-antagonist and calcium channel-blocker that acts by inhibit

Acts by plugging up the channels and limiting the entry of calcium into both smooth muscle cells of arteriolar walls and the cardiac muscle cells at higher doses.

  • Blocks L-type Ca2+ channels in smooth and cardiac muscle
  • Induces apoptosis of human primary and metastatic colon adenocarcinoma cells in vitro
  • Drug resistance reversal agent acting on Pgp, e.g. decrease renal tubule elimination of digoxin
  • Increases basal ATPase activity of Pgp
  • Substrate of Cyp3A4 and CYP2C6
CAS 152-11-4
Melting Point 140°C to 150°C (literature)
Molecular Formula C27H39ClN2O4
Quantity 1 g
Synonym verapamil hydrochloride, verapamil hcl, manidon, calcan hydrochloride, cardibeltin, cardiabeltin, cardioprotect, veroptinstada, calaptin, caveril
Solubility Information Soluble in water (7g/100mL); sparingly soluble in chloroform; soluble in ethanol (26mg/mL), isopropanol, acetone, ethyl acetate; freely soluble in methanol (>100mg/mL), DMF (>100mg/mL); practically insoluble in ether.
InChI Key DOQPXTMNIUCOSY-UHFFFAOYSA-N
SMILES CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl
IUPAC Name 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile;hydrochloride
Molecular Weight (g/mol) 491.069
PubChem CID 62969
Formula Weight 491.1
Physical Form Powder
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