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  7. XE 991 dihydrochloride, Tocris Bioscience™

XE 991 dihydrochloride, Tocris Bioscience™

Product Code. 30001293
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents

Potent and selective blocker of KV7 (KCNQ) voltage-gated potassium channels. Blocks KV7.2+7.3 (KCNQ2+3)/ M-currents (IC50 = 0.6 - 0.98 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 0.75 μM) but is less potent against KV7.1/minK channels (IC50 = 11.1 μM). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo.

Chemical Identifiers

CAS 122955-13-9
Molecular Formula C26H22Cl2N2O
Molecular Weight (g/mol) 449.375
InChI Key WOGWMARIFDNZON-UHFFFAOYSA-N
Synonym xe 991 dihydrochloride, 9 10h-anthracenone,10,10-bis 4-pyridinylmethyl, 10,10-bis 4-pyridinylmethyl-9 10h-anthracenone dihydrochloride, acmc-20emsx, xe991 dihydrochloride, 10,10-bis pyridin-4-ylmethyl anthracen-9-one dihydrochloride, 10,10-bis pyridin-4-yl methyl anthracen-9 10h-one-hydrogen chloride 1/2
PubChem CID 45073462
IUPAC Name 10,10-bis(pyridin-4-ylmethyl)anthracen-9-one;dihydrochloride
SMILES C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3C2(CC4=CC=NC=C4)CC5=CC=NC=C5.Cl.Cl

Specifications

Quantity 10 mg
Formula Weight 449.37
Percent Purity >99%
Chemical Name or Material XE 991 dihydrochloride
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