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Zap-70 Monoclonal Antibody (1E7.2), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen 376500

Product Code. 10630474

  • 4185.00 SEK / Each

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For Research Use Only. All usage must comply with product instructions.

This item is not returnable. View return policy

Description

Description

ZAP-70 is a cytosolic protein tyrosine kinase that is a member of the Syk family of proteins. ZAP-70 is expressed exclusively in T-cells and natural killer cells and is required for T-cell receptor activation. Upon T cell antigen receptor (TCR) engagement, ZAP70 is phosphorylated on tyrosines 292, 315 and 319 in the interdomain B, located between the SH2 and kinase domains. Phosphorylation of both tyrosines 315 (a Vav binding site) and 319 (a Lck binding site) enhances ZAP70 function in mediating lymphocyte signaling, while tyrosine 292 terminates the transient activation of ZAP70 and attentuates lymphocyte signaling.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Zap-70
Monoclonal
0.5 mg/mL
PBS with 0.1% sodium azide; pH 7.4
P43403, P43404
ZAP70
Synthetic peptide derived from the region between the second SH2 domain and the kinase domain of human ZAP-70
100 μg
Primary
Human, Mouse
Antibody
IgG1
Flow Cytometry, Immunoprecipitation, Western Blot
1E7.2
Unconjugated
ZAP70
70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; ADMIO2; EC 2.7.10.2; FLJ17670; FLJ17679; I79_004087; IMD48; kinase ZAP70; mrtle; mur; Selective T cell defect; Srk; STCD; STD; syk-related protein tyrosine kinase; syk-related tyrosine kinase; Tyrosine-protein kinase ZAP-70; Tyrosine-protein kinase ZAP-70;TZK; TZK; ZA70; Zap70; ZAP-70; Zeta chain associated protein kinase 70kDa; zeta chain of T cell receptor associated protein kinase; zeta chain of T cell receptor associated protein kinase 70; zeta chain of T cell receptor associated protein kinase 70kDa; zeta-chain (TCR) associated protein kinase; zeta-chain (TCR) associated protein kinase 70; zeta-chain (TCR) associated protein kinase 70kDa; zeta-chain associated protein kinase 70kDa; zeta-chain associated protein kinase, 70kD
Mouse
Protein A
RUO
22637, 7535
-20°C
Liquid
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