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Zileuton, Tocris Bioscience™

Product Code. 18083982
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

5-LOX inhibitor; orally bioavailable

Orally active 5-lipoxygenase (5-LOX) inhibitor that inhibits LTB4 synthesis (IC50 values are 0.56, 2.3 and 2.6 μM in dog, rat and human blood respectively). Inhibits antigen-induced contraction of tracheal strips in vitro (IC50 = 6 μM) and exhibits antiasthmatic activity in vivo. Also weakly inhibits CYP1A2 (Ki = 66 - 98 μM).

Chemical Identifiers

CAS 111406-87-2
Molecular Formula C11H12N2O2S
Molecular Weight (g/mol) 236.29
MDL Number MFCD00866097
InChI Key MWLSOWXNZPKENC-UHFFFAOYNA-N
Synonym zileuton, zyflo, leutrol, zileutonum, 1-1-benzo b thiophen-2-yl ethyl-1-hydroxyurea, zyflo cr, zileutonum inn-latin, abbott 64077, n-1-benzo b thien-2-ylethyl-n-hydroxyurea, zyflo tn
PubChem CID 60490
ChEBI CHEBI:10112
IUPAC Name 1-[1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea
SMILES CC(N(O)C(N)=O)C1=CC2=CC=CC=C2S1

Specifications

Quantity 10 mg
Formula Weight 236.29
Percent Purity >99%
Chemical Name or Material Zileuton
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