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STEMCELL Technologies Annexin V, APC
A cellular protein for detection of apoptotic cells, PE-conjugated
Brand: STEMCELL Technologies 100-0329
This item is not returnable.
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Description
- Annexin V is a member of the annexin family of proteins that bind to membrane phospholipids in the presence of calcium
- This dye has high affinity for phosphatidylserine (PS) that is present in the inner leaflet of the plasma membrane
- During early-stage cell apoptosis, PS is translocated from the inner to the outer leaflet of the plasma membrane, exposing it to the external environment
- Annexin V, a characteristic marker for early cell apoptosis, detects the translocation of PS to the external environment
- Annexin V is used along with viability dyes such as 7-AAD (Catalog #75001) or Propidium Iodide (Catalog #75002)
- The process of PS translocation occurs prior to the loss of membrane integrity
- Therefore, as cells progress through apoptosis and towards necrosis, the cell membrane is compromised and consequently, viability dyes pass into the cell
- Thus, cells undergoing early apoptosis stain positive for Annexin V and negative for viability dyes, while apoptotic death or necrosis is characterized by positive staining for both Annexin V and the viability dye
Specifications
| 100 Tests | |
| Flow Cytometry | |
| APC (Allophycocyanin) |