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MEK1 Mouse, Unlabeled, Clone: 25/MEK1, BD
Mouse Monoclonal Antibody
3685.00 SEK - 4105.00 SEK
Specifications
| Antigen | MEK1 |
|---|---|
| Clone | 25/MEK1 |
| Concentration | 250μg/mL |
| Applications | Western Blot |
| Classification | Monoclonal |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15885269
|
BD Biosciences
610121 |
50 μg |
3685.00 SEK
1 set |
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|
15895269
|
BD Biosciences
610122 |
150 μg |
4105.00 SEK
1 set |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
MEK1 (MapK/ERK Kinase 1) is a 45kDa member of the MEK family of dual specificity kinases. MEK is activated by a variety of cellular serine/threonine kinases including c-Raf, A-Raf, c-mos, and MEK Kinase-1. Activated MEK phosphorylates MAP kinase (ERK) at threonine and tyrosine residues. This results in activation of ERK and its signaling pathway. MEK is highly specific for ERK and various MEKs preferentially phosphorylate individual ERK isoforms. MEK1 only activates ERK1 and ERK2. This specificity may result from variations in
ERK regions that are known as the phosphorylation lip and kinase backbone. MEK's localization is cytoplasmic, but mitogenic stimulation induces a mass translocation to the nucleus. Mechanisms behind this nuclear translocation remain unknown. However, MEK contains an N-terminal nuclear export signal (NES) that mediates its rapid exodus from the nucleus and restores its unstimulated cellular distribution.
Host Species: Mouse
Clone: 25
Isotype: IgG2a
Species Reactivity: Human
Immunogen: Human MEK1 aa. 2-124
Formula Weight [Chemical]: 45kDa
Bioimaging, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Specifications
| MEK1 | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG2a | |
| Affinity Purified |
| 25/MEK1 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Canine, Chicken, Frog, Human, Mouse, Rat | |
| Human MEK1 aa. 2-124 | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.