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Paxillin Mouse, Unlabeled, Clone: 349, BD
Mouse Monoclonal Antibody
Brand: BD Biosciences 610051
Additional Details : Weight : 0.01000kg
Description
A number of cytoskeletal proteins are tyrosine phosphorylated in Rous sarcoma virus-transformed chick embryo fibroblasts. One of these is the 68 kDa paxillin protein. Paxillin is a cytoskeletal component that localizes to the focal adhesions at the ends of actin stress fibers. It is also present in the focal adhesions of Madin-Darby canine kidney epithelial cells, but is absent from the cell adherens junctions of these cells. Paxillin purified from chicken gizzard migrates as a diffuse band on SDS-PAGE with molecular weight of 65-70 kDa. It binds to the rod domain of vinculin, another focal adhesion protein. It is thought that phosphorylation of paxillin may have a role in that disassembly of focal adhesions and stress fibers during transformation.Specifications
Paxillin | |
Monoclonal | |
1.0mg/mL | |
Aqueous buffered solution containing glycerol and ≤0.09% sodium azide. | |
Chicken Paxillin aa. 1 to 557 | |
50 μg | |
Cell Biology | |
Canine, Chicken, Human, Mouse, Rat | |
IgG1 |
Western Blot | |
349 | |
Unconjugated | |
Mouse | |
Affinity Purified | |
RUO | |
Primary | |
Store undiluted at -20°C. |
For Research Use Only.