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Eurofins DiscoverX ATR/ATRIP Protein, Active
Active, Recombinant, human FLAG-tagged ATR full length (GenBank NM_001184.3*) and recombinant, human cMyc-tagged ATRIP full length, for use in Kinase Assays
Brand: Eurofins DiscoverX 14-953
Additional Details : Weight : 4.70710kg
Description
Serine/threonine-protein kinase ATR activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. ATR interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage.
GenBank NM_001184.3* / GenBank AF451323.1 * Note: the recombinant ATR contains the amino acid substitution M211T with reference toGenBank NM_001184.3. M211T is reported inGenBank XM_001131387.1.
Specifications
| mg/mL of enzyme in storage buffer. | |
| 10 μg | |
| Recombinant | |
| Recombinant enzyme expressed in mammalian cells | |
| Combined ≥43% ration 1:1 to 2:1 ATR:ATRIP |
| 303 kDa (ATR) and 87 kDa (ATRIP) | |
| Human | |
| ATR-FLAG-tag / ATRIP-cMyc-tag | |
| Full-length | |
| ATR/ATRIP, active |