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Eurofins DiscoverX CAM KINASE IIA Protein, Active
Active, N-terminal 6His-tagged, recombinant, human CaM kinase IIα full length, expressed by baculovirus in Sf21 insect cells, for use in Kinase Assays.
Brand: Eurofins DiscoverX 14-962M
Additional Details : Weight : 4.70710kg
Description
CAM KINASE IIA belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene.
GenBank AF091486.1
Specifications
| mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. | |
| 250 μg | |
| Recombinant | |
| Recombinant enzyme expressed in Sf21 insect cells | |
| ≥77% |
| 55 kDa | |
| Human | |
| N-terminal 6His | |
| Full-length | |
| CaM Kinase IIα, active |