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STEMCELL Technologies GSA 10

Hedgehog pathway activator; Activates Smoothened (SMO)

Brand: STEMCELL Technologies 73172

Additional Details : Weight : 0.05000kg

Product Code. 17140182

Estimated Shipment: 16-08-2024
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Description

GSA 10 is an agonist of Smoothened (SMO), a cell surface receptor and mediator of the hedgehog signaling pathway
It is a quinolinecarboxamide derivative that binds in a distinct binding pocket from cyclopamine
GSA10 is active at an EC₅₀ of 1.2 μM in an alkaline phosphatase-based mouse mesenchymal cell line (C3H10T1/2) differentiation assay (Gorojankina et al.)
Promotes differentiation of multipotent mesenchymal progenitor cells into osteoblasts (Gorojankina et al.)

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