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HLA DQ Antibody (SPV-L3), Novus Biologicals™
Mouse Monoclonal Antibody has been used in 3 publications
Brand: Bio-Techne
This item is not returnable.
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Description
Ensure accurate, reproducible results in Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence
HLA DQ Monoclonal specifically detects HLA DQ in Human, Porcine samples. It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunofluorescence.Specifications
| HLA DQ | |
| Monoclonal | |
| 0.2 mg/mL | |
| Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Frozen 0.5 - 1.0 ug/ml, Immunofluorescence 0.5 - 1.0 ug/ml | |
| CD, CELIAC1DQ alpha 1 chain, DC-1 alpha chain, DQ-A1, FLJ27088, FLJ27328, GSE, HLA class II histocompatibility antigen, DQ(W3) alpha chain, HLA-DCA, HLA-DQA, leucocyte antigen DQA1, leukocyte antigen alpha chain, major histocompatibility complex, class II, DQ alpha 1, MGC149527, MHC class II antigen, MHC class II DQA1, MHC class II HLA-D alpha glycoprotein, MHC class II HLA-DQ-alpha-1, MHC class II surface glycoprotein, MHC HLA-DQ alpha | |
| Mouse | |
| 60 kDa | |
| 0.1 mg | |
| Adaptive Immunity, Asthma, Immunology | |
| 3117 | |
| Human, Porcine | |
| Purified |
| Flow Cytometry, Immunohistochemistry (Frozen), Immunofluorescence | |
| SPV-L3 | |
| Unconjugated | |
| 10mM PBS and 0.05% BSA with 0.05% Sodium Azide | |
| HLA-DQ | |
| T4-positive CTL clone HG-38 | |
| Protein A or G purified | |
| RUO | |
| Primary | |
| Recognizes a DQ antigen, which is a dimer of 60kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. This MAb strongly blocks cytotoxicity activity of T4-positive cytotoxic T cell clones. | |
| Store at 4C. | |
| IgG2a κ |
For Research Use Only