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Integrin beta 7, Rabbit anti-Human,Mouse, Clone: FIB27, Novus Biologicals™
Rabbit Monoclonal Antibody
Brand: Bio-Techne NBP2-81087-0.2MG
This item is not returnable.
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Description
Integrin beta 7 Monoclonal specifically detects Integrin beta 7 in Human, Mouse samples. It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Block/Neutralize.Specifications
| Integrin beta 7 | |
| Monoclonal | |
| 1 mg/mL | |
| Flow Cytometry, Immunoprecipitation, Block/Neutralize | |
| Gut homing receptor beta subunit, integrin beta 7 subunit, integrin beta-7, integrin, beta 7 | |
| Rabbit | |
| Protein A purified | |
| RUO | |
| Primary | |
| FIB27 binds specifically to both human and mouse Integrin beta 7 at epitope region Dl on which is involved in all a4b7-mediated adhesion events. Does not compete with DAKT32 for binding. FIB27 blocks LS722-induced TK1 cell aggregation (mAb LS722 is an activating anti-a4B7 antibody and induces aggregation via an a4B7-dependent pathway). Integrin beta 7 is one subunit is a heterodimer which makes up an intergin molecule. In the mouse beta-7 is selectively found on the majority of mature lymphocytes, whereas a small subpopulation of thymocytes and bone marrow cells express beta-7. Beta-7 is also expressed in variable amounts in CD4 T memory cells. Integrin molecules mediate cell-cell and cell-extracellular matrix adhesion and are involved in lymphocyte homing, leukocyte recruitment to inflammatory sites, myogenesis, hemopoiesis, and melanoma metastasis. | |
| Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. | |
| IgG κ |
| Flow Cytometry, Immunoprecipitation, Blocking Assay | |
| FIB27 | |
| Unconjugated | |
| PBS | |
| ITGB7 | |
| FIB27 was prepared by immunizing rats with TK1 cells. | |
| 0.2 mg | |
| Signal Transduction | |
| 3695 | |
| Human, Mouse | |
| Purified |
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