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Eurofins DiscoverX LATS1 Protein, Active
Active, N-Terminal GST-tagged, recombinant, human LATS1, amino acid residues 589-end and N-Terminal 6His-tagged, recombinant, human MOBKL1A, full length, for use in Kinase Assays.
Brand: Eurofins DiscoverX 14-988M
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Description
LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
GenBank NM_004690.2 / GenBank BC038112.1
Specifications
| mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. | |
| 250 μg | |
| Recombinant | |
| Recombinant enzyme expressed in Sf21 insect cells | |
| Combined ≥66% |
| 90 kDa (LATS1) and 30 kDa (MOBKL1A) | |
| Human | |
| N-terminal GST / N-terminal 6His | |
| Truncated | |
| LATS1, active |
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Eurofins DiscoverX LATS1 Protein, Active
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