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Eurofins DiscoverX MARK1 Protein, Active
Active, N-terminal 6His-tagged, recombinant, human MARK1, amino acids 2-end, for use in Kinase Assays.
Brand: Eurofins DiscoverX 14-651
This item is not returnable.
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Description
MARK (MAP/microtubule affinity-regulating kinase) phosphorylates the microtubule-associated proteins tau, MAP2, and MAP4 on their microtubule-binding domain, causing their dissociation from microtubules and increased microtubule dynamics. Overexpression of MARK1 or MARK2 in cells leads to hyperphosphorylation of MAPs and to disruption of the microtubule array, resulting in morphological changes and cell death.
GenBank AF154845. The recombinant protein contains the amino acid substitutions V16E and T20S with reference to AF154845. These mutations are reported inGenBank NM_018650, AK098103 and BC068608.
Specifications
| mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. | |
| 10 μg | |
| Recombinant | |
| Recombinant enzyme expressed in Sf21 insect cells | |
| ≥42% |
| 92.7 kDa | |
| Human | |
| N-terminal 6His | |
| Truncated | |
| MARK1, active |
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