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Eurofins DiscoverX MARK1 Protein, Active
Active, N-terminal 6His-tagged, recombinant, human MARK1, amino acids 2-end, for use in Kinase Assays.
5796.39 SEK - 44240.30 SEK
Specifications
| Formulation | mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. |
|---|---|
| Molecular Weight (g/mol) | 92.7 kDa |
| Species | Human |
| Recombinant | Recombinant |
| Protein Tag | N-terminal 6His |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17380494
|
Eurofins DiscoverX
14-651 |
10 μg |
5796.39 SEK
10µg |
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|
17390494
|
Eurofins DiscoverX
14-651M |
250 μg |
44240.30 SEK
250µg |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
MARK (MAP/microtubule affinity-regulating kinase) phosphorylates the microtubule-associated proteins tau, MAP2, and MAP4 on their microtubule-binding domain, causing their dissociation from microtubules and increased microtubule dynamics. Overexpression of MARK1 or MARK2 in cells leads to hyperphosphorylation of MAPs and to disruption of the microtubule array, resulting in morphological changes and cell death.
GenBank AF154845. The recombinant protein contains the amino acid substitutions V16E and T20S with reference to AF154845. These mutations are reported inGenBank NM_018650, AK098103 and BC068608.
Specifications
| mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. | |
| Human | |
| N-terminal 6His | |
| Truncated | |
| MARK1, active |
| 92.7 kDa | |
| Recombinant | |
| Recombinant enzyme expressed in Sf21 insect cells | |
| ≥42% |
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