missing translation for 'onlineSavingsMsg'
Learn More
Learn More
STEMCELL Technologies NU7026
NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)
Brand: STEMCELL Technologies 74174
Additional Details : Weight : 0.05000kg
Description
- NU7026 is an inhibitor of DNA-dependent protein kinase (DNA-PK), an enzyme involved in the non-homologous end joining (NHEJ) DNA repair pathway
- NU7026 sensitizes cells to radiation and has potential for anticancer therapies (Veuger et al.) NU7026 is also reported to increase the efficiency of homology-directed repair (HDR) in CRISPR-Cas9 genome editing (Riesenberg & Maricic; Zhang et al.)
- Increases precise genome editing by promoting HDR at the expense of NHEJ in human pluripotent stem cells (Riesenberg & Maricic; Zhang et al.)
- Sensitizes human cancer cell lines to DNA double-strand break-inducing therapy (chemo- or radio-therapy) by inhibiting DNA-PK activity and inducing cell cycle arrest at G2/M phase (Albarakati et al.; Ma et al.; Niazi et al.; Willmore et al.; Yang et al.)
Specifications
| 154447-35-5 | |
| 25 mg | |
| ≥95% |
| LY293646; DNA-PK Inhibitor II | |
| C17H15NO3 |