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STEMCELL Technologies NU7026

NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)

1586.25 SEK - 6235.65 SEK

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Product Code	Brand	Quantity	Price	Quantity & Availability
Product Code	Brand	Quantity	Price	Quantity & Availability
17120342 View Documents Promotion Details missing translation for 'viewProductCertificates'	STEMCELL Technologies 74172	5 mg	1586.25 SEK 5mg View alternative products Save Up to »	Estimated Shipment: 20-09-2024 Log in to see stock.	Please sign in to purchase this item. Need a web account? Register with us today!

17130342 View Documents Promotion Details missing translation for 'viewProductCertificates'	STEMCELL Technologies 74174	25 mg	6235.65 SEK 25mg View alternative products Save Up to »	Estimated Shipment: 20-09-2024 Log in to see stock.	Please sign in to purchase this item. Need a web account? Register with us today!

Description

NU7026 is an inhibitor of DNA-dependent protein kinase (DNA-PK), an enzyme involved in the non-homologous end joining (NHEJ) DNA repair pathway
NU7026 sensitizes cells to radiation and has potential for anticancer therapies (Veuger et al.) NU7026 is also reported to increase the efficiency of homology-directed repair (HDR) in CRISPR-Cas9 genome editing (Riesenberg & Maricic; Zhang et al.)
Increases precise genome editing by promoting HDR at the expense of NHEJ in human pluripotent stem cells (Riesenberg & Maricic; Zhang et al.)
Sensitizes human cancer cell lines to DNA double-strand break-inducing therapy (chemo- or radio-therapy) by inhibiting DNA-PK activity and inducing cell cycle arrest at G2/M phase (Albarakati et al.; Ma et al.; Niazi et al.; Willmore et al.; Yang et al.)

Specifications

Description