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STEMCELL Technologies NU7026
NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)
1586.25 SEK - 6235.65 SEK
Specifications
CAS | 154447-35-5 |
---|---|
Synonym | LY293646; DNA-PK Inhibitor II |
Molecular Formula | C17H15NO3 |
Purity | ≥95% |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17120342
|
STEMCELL Technologies
74172 |
5 mg |
1586.25 SEK
5mg |
Estimated Shipment: 20-09-2024 Log in to see stock. |
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17130342
|
STEMCELL Technologies
74174 |
25 mg |
6235.65 SEK
25mg |
Estimated Shipment: 20-09-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
Description
- NU7026 is an inhibitor of DNA-dependent protein kinase (DNA-PK), an enzyme involved in the non-homologous end joining (NHEJ) DNA repair pathway
- NU7026 sensitizes cells to radiation and has potential for anticancer therapies (Veuger et al.) NU7026 is also reported to increase the efficiency of homology-directed repair (HDR) in CRISPR-Cas9 genome editing (Riesenberg & Maricic; Zhang et al.)
- Increases precise genome editing by promoting HDR at the expense of NHEJ in human pluripotent stem cells (Riesenberg & Maricic; Zhang et al.)
- Sensitizes human cancer cell lines to DNA double-strand break-inducing therapy (chemo- or radio-therapy) by inhibiting DNA-PK activity and inducing cell cycle arrest at G2/M phase (Albarakati et al.; Ma et al.; Niazi et al.; Willmore et al.; Yang et al.)
Specifications
154447-35-5 | |
LY293646; DNA-PK Inhibitor II | |
C17H15NO3 | |
≥95% |