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Eurofins DiscoverX Plk1 Protein, Active
Active, N-terminal 6His tagged, recombinant, human Plk1, for use in Kinase Assays.
Brand: Eurofins DiscoverX 14-777
This item is not returnable.
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Description
Polo-like kinases (PLKs) are a family of serine/threonine kinases related to the polo gene product of Drosophila melanogaster, originally identified from a mitotic mutant that displayed abnormal spindle poles. PLKs play essential roles in several stages of mitosis and cytokinesis with a dynamic pattern of localization to centrosomes, kinetochores and central spindle structures during the cell cycle. PLK1 has been shown to be overexpressed in many human tumours, such as non-small cell lung cancer, squamous cell carcinomas of the head and neck, melanomas, oropharyngeal carcinomas, and ovarian and endometrial carcinomas.
GenBank NM_005030
Specifications
| mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. | |
| 10 μg | |
| Recombinant | |
| Recombinant protein expressed in Sf21 insect cells | |
| ≥72% |
| 69.3 kDa | |
| Human | |
| N-terminal 6His | |
| Full-length | |
| Plk1, active |