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Eurofins DiscoverX PRAK Protein, Unactive
Unactive, recombinant full-length human PRAK with an N-terminal His-tag, for use in Kinase Assays.
5796.39 SEK - 44240.30 SEK
Specifications
| Formulation | mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 150 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 50% glycerol, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Liquid at -20°C. |
|---|---|
| Molecular Weight (g/mol) | 55 kDa |
| Species | Human |
| Recombinant | Recombinant |
| Protein Tag | N-terminal 6His |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
17360144
|
Eurofins DiscoverX
14-335 |
50 μg |
5796.39 SEK
50µg |
Estimated Shipment: 29-08-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
|
17370144
|
Eurofins DiscoverX
14-335M |
250 μg |
44240.30 SEK
250µg |
Estimated Shipment: 29-08-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
Description
Protein Serine/Threonine Kinase MAPKAPK5 (mitogen-activated protein kinase activated protein kinase 5), also known as p38-regulated/activated protein kinase (PRAK), functions downstream of p38a and p38b in mediating signaling of the p38 pathway. This kinase can be activated in response to cellular stress and proinflammatory cytokines through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. MAPKAPK5 is localized predominantly in the cytoplasm and is constantly shuttled between the cytoplasm and the nucleus. MAPKAPK5 may play a role in balancing other MAPK pathways because overactivation of MAPKAPK5 can inhibit Ras mediated cell proliferation and gene activation. MAPKAPK5 inhibtion may facilitate cell differentiation, inflammation and cell proliferation.
EMBL AF032437. Protein is R291E with respect to this accession. This conflict is reported inGenBank AI300977, AL556217 and BI495728.
Specifications
| mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 150 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 50% glycerol, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Liquid at -20°C. | |
| Human | |
| N-terminal 6His | |
| Full-length | |
| PRAK, unactive |
| 55 kDa | |
| Recombinant | |
| Recombinant enzyme expressed in Sf21 insect cells | |
| ≥63% |