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Eurofins DiscoverX Pyk2 Protein, Active
Active, N-Terminal His6-tagged, recombinant, full-length, human Pyk2, for use in Kinase Assays.
Brand: Eurofins DiscoverX 14-567M
This item is not returnable.
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Description
Proline-rich tyrosine kinase 2 (PTK2B) (also called CAKb for cell adhesion kinase b, RAFTK for related adhesion focal tyrosine kinase, or CADTK for calcium-dependent tyrosine kinase) is a non-receptor tyrosine kinase structurally related to focal adhesion kinase (FAK). PTK2B interacts with Src family kinases and focal adhesion proteins such as p130Crk-associated substrate (p130Cas) and its homologue p105 human enhancer of filamentation 1 (HEF1). PTK2B is particularly enriched in pulmonary vascular endothelial cells and lung, a major organ site for tumor metastasis. Inhibitors of PTK2B may be useful in the treatment of lung cancer.
GenBank S80542
Specifications
| mg/mL of enzyme in Tris/HCl pH 7.5, 150 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. | |
| 250 μg | |
| Recombinant | |
| Recombinant enzyme expressed in Sf21 insect cells | |
| ≥53% |
| 117.2 kDa | |
| Human | |
| N-terminal 6His | |
| Full-length | |
| Pyk2, active |
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Eurofins DiscoverX Pyk2 Protein, Active
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