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Stat1 (pY701) Mouse, Alexa Fluor 647, Clone: 4A, BD
Mouse Monoclonal Antibody
Brand: BD Biosciences 562070
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Description
STAT ( S ignal t ransducer and activators of nterferon- S timulated G ene F actor 3 ) complex, which is the primary transcription activator induced by the binding of the interferon to a specific cell-surface receptor. Stat1 has two alternatively spliced isoforms, 91-kDa Stat1α and 84-kDa Stat1β; Stat1α has 38 additional C-terminal amino acids. In response to the binding of IFNα, IFNγ, EGF, PDGF, or CSF-1 to their respective receptors, the Stat1 subunits become tyrosine-phosphorylated at Y701, and the complex is translocated to the nucleus. This results in the formation of an active complex that includes the DNA-binding p48 subunit. This complex is responsible for modulating the transcription of the interferon-stimulated genes (ISGs).
The 4a monoclonal antibody recognizes the phosphorylated Y701 in Stat1 α.
Specifications
| Stat1 (pY701) | |
| Monoclonal | |
| Alexa Fluor 647 | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Human, Mouse | |
| IgG2a |
| Flow Cytometry | |
| 4a | |
| Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
| Phosphorylated Human Stat1 Peptide | |
| 250 Tests | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
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