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STEMCELL Technologies Tamoxifen
Estrogen signaling pathway modulator; Modulates selective estrogen receptor and estrogen-related receptor
Brand: STEMCELL Technologies 72662
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Descrizione
- Tamoxifen is a selective estrogen receptor modulator (SERM), with tissue-specific antagonistic or agonistic effects
- Receptor activation leads to the formation of homo- and hetero-dimers, which in turn interact with accessory proteins to regulate gene transcription
- Tamoxifen is commonly used to activate Cre-ER in transgenic conditional models
- Used in transgenic models to induce Cre-mediated recombination in conjunction with Cre-ER, a fusion protein consisting of Cre recombinase and a mutant form of the estrogen receptor hormone-binding domain that specifically binds tamoxifen but not estrogen (Feil et al.; Zhang et al.)
- Inhibits growth in the human breast cancer cell line, MCF-7 (Katzenellenbogen et al.)
- Antagonist of estrogen receptor action in breast tissue and breast cancer cells (Abe et al.; Horwitz et al.)
Specifica
| 10540-29-1 | |
| 500 mg | |
| ≥95% |
| trans-Tamoxifen | |
| C26H29NO |