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STEMCELL Technologies Tamoxifen

Estrogen signaling pathway modulator; Modulates selective estrogen receptor and estrogen-related receptor

4349.70 SEK - 25323.30 SEK

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Products 3

Product Code	Brand	Quantity	Price	Quantity & Availability
Product Code	Brand	Quantity	Price	Quantity & Availability
17140102 View Documents Promotion Details missing translation for 'viewProductCertificates'	STEMCELL Technologies 72662	500 mg	4349.70 SEK 500mg View alternative products Save Up to »		Please sign in to purchase this item. Need a web account? Register with us today!

17150102 View Documents Promotion Details missing translation for 'viewProductCertificates'	STEMCELL Technologies 72664	5 g	14004.90 SEK 5g View alternative products Save Up to »		Please sign in to purchase this item. Need a web account? Register with us today!

17160102 View Documents Promotion Details missing translation for 'viewProductCertificates'	STEMCELL Technologies 72666	10 g	25323.30 SEK 10g View alternative products Save Up to »		Please sign in to purchase this item. Need a web account? Register with us today!

Description

Tamoxifen is a selective estrogen receptor modulator (SERM), with tissue-specific antagonistic or agonistic effects
Receptor activation leads to the formation of homo- and hetero-dimers, which in turn interact with accessory proteins to regulate gene transcription
Tamoxifen is commonly used to activate Cre-ER in transgenic conditional models
Used in transgenic models to induce Cre-mediated recombination in conjunction with Cre-ER, a fusion protein consisting of Cre recombinase and a mutant form of the estrogen receptor hormone-binding domain that specifically binds tamoxifen but not estrogen (Feil et al.; Zhang et al.)
Inhibits growth in the human breast cancer cell line, MCF-7 (Katzenellenbogen et al.)
Antagonist of estrogen receptor action in breast tissue and breast cancer cells (Abe et al.; Horwitz et al.)

Specifications

Description