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Tyrosinase Ab-1 Mouse Monoclonal Antibody, Epredia™
Provide accurate, reproducible results with the Epredia™ Tyrosinase Ab-1, Mouse Monoclonal Antibody.
Brand: Epredia MS-800-P1ABX
This item is not returnable.
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Description
Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients.Host Species: Mouse
Clone: T311
Isotype: IgG2a
Species Reactivity: Human, Dog and Cat. Weakly cross-reacts with Mouse. Others not known.
Epitope: aa 1-433
Immunogen: Recombinant tyrosinase protein
Molecular Weight: 70-80kDa
Positive Control: Melanoma cell lines and Melanoma
Cellular Localization: Cytoplasmic Ab-1 shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Staining of melanomas with Ab-1 showed tyrosinase in melanotic as well as amelanotic variants. Ab-1 is a useful marker for melanocytes and melanomas. Occasionally a minor band at 55kDa is also detected in Western Blotting
Recommended for:
- Immunohistochemistry (Formalin/paraffin)
- Western Blotting
- Immunofluorescence
- Immunocytology
Specifications
| Tyrosinase Ab-1 | |
| Monoclonal | |
| 1mg/mL | |
| Mouse | |
| 100 μL | |
| Cancer and Tumor Biology | |
| Canine, Feline, Human | |
| IgG2a |
| Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot | |
| T311 | |
| Unconjugated | |
| Recombinant tyrosinase protein | |
| IVD | |
| Primary | |
| Concentrated |
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