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STEMCELL Technologies U-0126

MEK/ERK pathway inhibitor; Inhibits MEK1 and MEK2

Brand:  STEMCELL Technologies 73524

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Product Code. 17100242

  • 6660.90 SEK / 10mg

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Description

Description

  • U-0126 is a selective, non-ATP competitive inhibitor of mitogen activated protein kinase kinase (MEK), inhibiting MEK1 and MEK2 with IC50 values of 72 nM and 58 nM, respectively (Favata et al.; Scherle et al.) It shows little or no inhibition at micromolar levels of other kinases such as ERK, protein kinase C (PKC), c-Jun N-terminal kinases (JNK), other MAP kinase kinases (MKK3, MKK4, MKK6), cyclin-dependent kinases (CDK2, CDK4), ABL, and RAF (Favata et al.) 1998)
  • U-0126 also antagonizes AP-1 transcription and selectively inhibits promoters containing AP-1 response elements (Favata et al.)
Specifications

Specifications

109511-58-2
10 mg
C18H16N6S2
≥98%
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