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STEMCELL Technologies U-0126
MEK/ERK pathway inhibitor; Inhibits MEK1 and MEK2
1291.95 SEK - 6660.90 SEK
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17100242
|
STEMCELL Technologies
73524 |
10 mg |
6660.90 SEK
10mg |
Estimated Shipment: 20-09-2024 Log in to see stock. |
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17190232
|
STEMCELL Technologies
73522 |
1 mg |
1291.95 SEK
1mg |
Estimated Shipment: 20-09-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
Description
- U-0126 is a selective, non-ATP competitive inhibitor of mitogen activated protein kinase kinase (MEK), inhibiting MEK1 and MEK2 with IC50 values of 72 nM and 58 nM, respectively (Favata et al.; Scherle et al.) It shows little or no inhibition at micromolar levels of other kinases such as ERK, protein kinase C (PKC), c-Jun N-terminal kinases (JNK), other MAP kinase kinases (MKK3, MKK4, MKK6), cyclin-dependent kinases (CDK2, CDK4), ABL, and RAF (Favata et al.) 1998)
- U-0126 also antagonizes AP-1 transcription and selectively inhibits promoters containing AP-1 response elements (Favata et al.)
Specifications
109511-58-2 | |
C18H16N6S2 | |
≥98% |