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Lifitegrast, MedChemExpress
MedChemExpress Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease.
Brand: Medchem Express HY-19344

Description
Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease.Specifications
Lifitegrast | |
Off-White | |
C29H24Cl2N2O7S | |
SAR 1118 SHP-606 | |
O=C(O)[C@H](CC1=CC=CC(S(=O)(C)=O)=C1)NC(C2=C(Cl)C3=C(CN(C(C4=CC=C5C=COC5=C4)=O)CC3)C=C2Cl)=O | |
615.48 | |
Research | |
COVID-19-immunoregulation |
1025967-78-5 | |
Research | |
50 mg | |
DMSO : ≥ 29 mg/mL (47.12 mM) | |
615.48 | |
99.09% | |
Solid |
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Research purposes only